› 1dgb

X-ray diffraction
2.2Å resolution

HUMAN ERYTHROCYTE CATALASE

Released:
DOI: 10.2210/pdb1dgb/pdb
PDB entry 1dgb coloured by chain, front view.
PDB entry 1dgb coloured by chain, side view.
PDB entry 1dgb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Putnam CD, Arvai AS, Bourne Y, Tainer JA
J Mol Biol 296 295-309 (2000)
PMID: 10656833

Function and Biology Details

Reaction catalysed: 
2 H(2)O(2) = O(2) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catalase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 498 amino acids
Theoretical weight: 56.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04040 (Residues: 4-501; Coverage: 95%)
Gene name: CAT
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 4 x HEM
1 bound ligand:
Ligand NDP 2 x NDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 83.497Å b: 139.934Å c: 227.891Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.172 0.227

Quick links

Citations

33 review citations

The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium.
Imlay JA. (2013)
32 more

12 mentions without citation

Evidence for assembly of prions with left-handed beta-helices into trimers.
Govaerts et al. (2004)
11 more