› 1dgh

X-ray diffraction
2Å resolution

HUMAN ERYTHROCYTE CATALASE 3-AMINO-1,2,4-TRIAZOLE COMPLEX

Released:
DOI: 10.2210/pdb1dgh/pdb
PDB entry 1dgh coloured by chain, front view.
PDB entry 1dgh coloured by chain, side view.
PDB entry 1dgh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Putnam CD, Arvai AS, Bourne Y, Tainer JA
J Mol Biol 296 295-309 (2000)
PMID: 10656833

Function and Biology Details

Reaction catalysed: 
2 H(2)O(2) = O(2) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137331 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catalase Chains: A, C
Molecule details ›
Chains: A, C
Length: 498 amino acids
Theoretical weight: 56.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04040 (Residues: 4-501; Coverage: 95%)
Gene name: CAT
Sequence domains:
Structure domains:
Catalase Chains: B, D
Molecule details ›
Chains: B, D
Length: 498 amino acids
Theoretical weight: 56.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04040 (Residues: 4-501; Coverage: 95%)
Gene name: CAT
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 4 x HEM
1 bound ligand:
Ligand NDP 2 x NDP
1 modified residue:
Ligand 3AH 2 x 3AH

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 84.028Å b: 140.639Å c: 231.346Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.173 0.21

Quick links

Citations

33 review citations

The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium.
Imlay JA. (2013)
32 more

13 mentions without citation

An in silico investigation on the inhibitory potential of the constituents of Pomegranate juice on antioxidant defense mechanism: Relevance to neurodegenerative diseases.
Mazumder et al. (2019)
12 more