› 1dlb

X-ray diffraction
2Å resolution

HELICAL INTERACTIONS IN THE HIV-1 GP41 CORE REVEALS STRUCTURAL BASIS FOR THE INHIBITORY ACTIVITY OF GP41 PEPTIDES

Released:
DOI: 10.2210/pdb1dlb/pdb
PDB entry 1dlb coloured by chain, front view.
PDB entry 1dlb coloured by chain, side view.
PDB entry 1dlb coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Helical interactions in the HIV-1 gp41 core reveal structural basis for the inhibitory activity of gp41 peptides.
Shu W, Liu J, Ji H, Radigen L, Jiang S, Lu M
Biochemistry 39 1634-42 (2000)
PMID: 10677212

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.86 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-655; Coverage: 8%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: R3
Unit cell:
a: 52.382Å b: 52.382Å c: 60.482Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.206 0.243
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.
Julien et al. (2012)
6 more

3 mentions without citation

Current progress in antiviral strategies.
Lou et al. (2014)
2 more