› 1dn2

X-ray diffraction
2.7Å resolution

FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2

Released:
DOI: 10.2210/pdb1dn2/pdb
PDB entry 1dn2 coloured by chain, front view.
PDB entry 1dn2 coloured by chain, side view.
PDB entry 1dn2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Convergent solutions to binding at a protein-protein interface.
DeLano WL, Ultsch MH, de Vos AM, Wells JA
Science 287 1279-83 (2000)
PMID: 10678837

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134863 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 120-326; Coverage: 52%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
ENGINEERED PEPTIDE Chains: E, F
Molecule details ›
Chains: E, F
Length: 14 amino acids
Theoretical weight: 1.53 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P21
Unit cell:
a: 67.541Å b: 60.825Å c: 68.174Å
α: 90° β: 103.87° γ: 90°
R-values:
R R work R free
0.2 0.194 0.252
Expression system: Not provided

Quick links

Citations

82 review citations

Fcgamma receptors as regulators of immune responses.
Nimmerjahn et al. (2008)
81 more

29 mentions without citation

Neonatal Fc receptor and IgG-based therapeutics.
Kuo et al. (2011)
28 more