› 1dol

X-ray diffraction
2.4Å resolution

MONOCYTE CHEMOATTRACTANT PROTEIN 1, I-FORM

Released:
DOI: 10.2210/pdb1dol/pdb
PDB entry 1dol coloured by chain, front view.
PDB entry 1dol coloured by chain, side view.
PDB entry 1dol coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions.
Lubkowski J, Bujacz G, Boqué L, Domaille PJ, Handel TM, Wlodawer A
Nat Struct Biol 4 64-9 (1997)
PMID: 8989326

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-146611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 2 Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13500 (Residues: 24-99; Coverage: 100%)
Gene names: CCL2, MCP1, SCYA2
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: I4122
Unit cell:
a: 84.86Å b: 84.86Å c: 52.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.275
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Monocyte chemoattractant protein-1 (MCP-1): an overview.
Deshmane et al. (2009)
20 more

23 mentions without citation

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
22 more