› 1dow

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF A CHIMERA OF BETA-CATENIN AND ALPHA-CATENIN

Released:
DOI: 10.2210/pdb1dow/pdb
PDB entry 1dow coloured by chain, front view.
PDB entry 1dow coloured by chain, side view.
PDB entry 1dow coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the dimerization and beta-catenin-binding region of alpha-catenin.
Pokutta S, Weis WI
Mol Cell 5 533-43 (2000)
PMID: 10882138

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150676 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 205 amino acids
Theoretical weight: 22.69 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26231 (Residues: 57-261; Coverage: 23%)
Gene names: Catna1, Ctnna1
Structure domains: Alpha-catenin/vinculin-like
Catenin beta-1 Chain: B
Molecule details ›
Chain: B
Length: 32 amino acids
Theoretical weight: 3.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02248 (Residues: 118-149; Coverage: 4%)
Gene names: Catnb, Ctnnb1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL1-5
Spacegroup: P212121
Unit cell:
a: 53Å b: 62.62Å c: 63.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.233
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Hartsock et al. (2008)
43 more

16 mentions without citation

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
15 more