Function and Biology Details
Reaction catalysed:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146447 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Replication protein A 32 kDa subunit
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Replication protein A C terminal
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Length: 99 amino acids
Theoretical weight: 10.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P15927 (Residues: 172-270; Coverage: 37%)
Sequence domains: Replication protein A C terminal
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Uracil-DNA glycosylase
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
DISTANCE GEOMETRY SIMULATED ANNEALING
Expression systems:
- Escherichia coli
- Not provided
