Function and Biology Details
Reaction catalysed:
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Hydroxymethylglutaryl-CoA reductase, class I/II
- Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
- Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
- Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
- Hydroxymethylglutaryl-CoA reductase, N-terminal
- Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
- Hydroxymethylglutaryl-CoA reductase, metazoan
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (preferred)
PDBe Complex ID:
PDB-CPX-137325 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Molecule details ›
Chains: A, B, C, D
Length: 467 amino acids
Theoretical weight: 50.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
Length: 467 amino acids
Theoretical weight: 50.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P04035 (Residues: 425-888; Coverage: 52%)
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
