› 1dr9

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)

Released:
DOI: 10.2210/pdb1dr9/pdb
PDB entry 1dr9 coloured by chain, front view.
PDB entry 1dr9 coloured by chain, side view.
PDB entry 1dr9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dimerization of a soluble form of B7-1.
Ikemizu S, Gilbert RJ, Fennelly JA, Collins AV, Harlos K, Jones EY, Stuart DI, Davis SJ
Immunity 12 51-60 (2000)
PMID: 10661405

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152638 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-lymphocyte activation antigen CD80 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P33681 (Residues: 35-235; Coverage: 79%)
Gene names: CD28LG, CD28LG1, CD80, LAB7
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: I4122
Unit cell:
a: 57.28Å b: 57.28Å c: 298.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.28
Expression system: Escherichia coli

Quick links

Citations

53 review citations

The B7-CD28 superfamily.
Sharpe et al. (2002)
52 more

18 mentions without citation

CD80-Fc fusion protein as a potential cancer immunotherapy strategy.
Wang et al. (2024)
17 more