› 1drz

X-ray diffraction
2.3Å resolution

U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX

Released:
DOI: 10.2210/pdb1drz/pdb
PDB entry 1drz coloured by chain, front view.
PDB entry 1drz coloured by chain, side view.
PDB entry 1drz coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of a hepatitis delta virus ribozyme.
Ferré-D'Amaré AR, Zhou K, Doudna JA
Nature 395 567-74 (1998)
PMID: 9783582

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140464 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
U1 small nuclear ribonucleoprotein A Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09012 (Residues: 2-98; Coverage: 34%)
Gene name: SNRPA
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
RNA (HEPATITIS DELTA VIRUS GENOMIC RIBOZYME) Chain: B
Molecule details ›
Chain: B
Length: 72 nucleotides
Theoretical weight: 23.18 KDa
Source organism: Hepatitis delta virus
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand MG 3 x MG
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: R32
Unit cell:
a: 109.35Å b: 109.35Å c: 190.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.281 0.281 0.284
Expression system: Escherichia coli

Quick links

Citations

128 review citations

The noncoding RNA revolution-trashing old rules to forge new ones.
Cech et al. (2014)
127 more

12 mentions without citation

Trendspotting in the Protein Data Bank.
Berman et al. (2013)
11 more