› 1dt7

Solution NMR

SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

Released:
DOI: 10.2210/pdb1dt7/pdb
PDB entry 1dt7 coloured by chain, ensemble of 40 models, front view.
PDB entry 1dt7 coloured by chain, ensemble of 40 models, side view.
PDB entry 1dt7 coloured by chain, ensemble of 40 models, top view.
Source organisms:
Primary publication:
Structure of the negative regulatory domain of p53 bound to S100B(betabeta).
Rustandi RR, Baldisseri DM, Weber DJ
Nat Struct Biol 7 570-4 (2000)
PMID: 10876243

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138094 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein S100-B Chains: A, B
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 10.76 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04631 (Residues: 1-92; Coverage: 100%)
Gene name: S100b
Sequence domains:
Structure domains: EF-hand
Isoform 7 of Cellular tumor antigen p53 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 22 amino acids
Theoretical weight: 2.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637-7 (Residues: 235-256; Coverage: 8%)
Gene names: P53, TP53

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

44 review citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.
Donato R. (2001)
43 more

43 mentions without citation

Classification of intrinsically disordered regions and proteins.
van der Lee et al. (2014)
42 more