› 1dt9

X-ray diffraction
2.7Å resolution

THE CRYSTAL STRUCTURE OF HUMAN EUKARYOTIC RELEASE FACTOR ERF1-MECHANISM OF STOP CODON RECOGNITION AND PEPTIDYL-TRNA HYDROLYSIS

Released:
DOI: 10.2210/pdb1dt9/pdb
PDB entry 1dt9 coloured by chain, front view.
PDB entry 1dt9 coloured by chain, side view.
PDB entry 1dt9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis.
Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings BA, Barford D
Cell 100 311-21 (2000)
PMID: 10676813

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic peptide chain release factor subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 437 amino acids
Theoretical weight: 49.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62495 (Residues: 1-437; Coverage: 100%)
Gene names: ERF1, ETF1, RF1, SUP45L1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P43212
Unit cell:
a: 77.08Å b: 77.08Å c: 194.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.246 0.314

Quick links

Citations

62 review citations

Ribosome structure and the mechanism of translation.
Ramakrishnan V. (2002)
61 more

20 mentions without citation

Translation Termination and Ribosome Recycling in Eukaryotes.
Hellen CUT. (2018)
19 more