› 1duj

Solution NMR

SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2

Released:
DOI: 10.2210/pdb1duj/pdb
PDB entry 1duj coloured by chain, front view.
PDB entry 1duj coloured by chain, side view.
PDB entry 1duj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G
Nat Struct Biol 7 224-9 (2000)
PMID: 10700282

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitotic spindle assembly checkpoint protein MAD2A Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 21.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13257 (Residues: 11-195; Coverage: 90%)
Gene names: MAD2, MAD2L1
Sequence domains: HORMA domain
Structure domains: HORMA domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The spindle-assembly checkpoint in space and time.
Musacchio et al. (2007)
26 more

24 mentions without citation

BUB1 and BUBR1: multifaceted kinases of the cell cycle.
Bolanos-Garcia et al. (2011)
23 more