› 1e04

X-ray diffraction
2.6Å resolution

PLASMA BETA ANTITHROMBIN-III

Released:
DOI: 10.2210/pdb1e04/pdb
PDB entry 1e04 coloured by chain, front view.
PDB entry 1e04 coloured by chain, side view.
PDB entry 1e04 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of beta-antithrombin and the effect of glycosylation on antithrombin's heparin affinity and activity.
McCoy AJ, Pei XY, Skinner R, Abrahams JP, Carrell RW
J Mol Biol 326 823-33 (2003)
PMID: 12581643

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Antithrombin-III Chains: I, L
Molecule details ›
Chains: I, L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand MAN 1 x MAN
Ligand GOL 2 x GOL
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P21
Unit cell:
a: 62.05Å b: 99.336Å c: 88.593Å
α: 90° β: 102.29° γ: 90°
R-values:
R R work R free
0.205 0.205 0.243

Quick links

Citations

16 review citations

Serpin structure, function and dysfunction.
Huntington JA. (2011)
15 more

9 mentions without citation

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
8 more