› 1e4u

Solution NMR

N-terminal RING finger domain of human NOT-4

Released:
DOI: 10.2210/pdb1e4u/pdb
PDB entry 1e4u coloured by chain, ensemble of 30 models, front view.
PDB entry 1e4u coloured by chain, ensemble of 30 models, side view.
PDB entry 1e4u coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers.
Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R
J Biol Chem 276 10185-90 (2001)
PMID: 11087754

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CCR4-NOT transcription complex subunit 4 Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95628 (Residues: 1-78; Coverage: 14%)
Gene names: CNOT4, NOT4
Sequence domains: RING/Ubox like zinc-binding domain
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Global control of gene expression in yeast by the Ccr4-Not complex.
Collart MA. (2003)
12 more

2 mentions without citation

Metabotropic glutamate receptors: from the workbench to the bedside.
Nicoletti et al. (2011)
1 more