› 1edm

X-ray diffraction
1.5Å resolution

EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX

Released:
DOI: 10.2210/pdb1edm/pdb
PDB entry 1edm coloured by chain, front view.
PDB entry 1edm coloured by chain, side view.
PDB entry 1edm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.
Rao Z, Handford P, Mayhew M, Knott V, Brownlee GG, Stuart D
Cell 82 131-41 (1995)
PMID: 7606779

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor IXa light chain Chains: B, C
Molecule details ›
Chains: B, C
Length: 39 amino acids
Theoretical weight: 4.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00740 (Residues: 92-130; Coverage: 9%)
Gene name: F9
Sequence domains: EGF-like domain

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P43212
Unit cell:
a: 40.3Å b: 40.3Å c: 98.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.157 not available
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Plant receptor-like kinase gene family: diversity, function, and signaling.
Shiu et al. (2001)
33 more

23 mentions without citation

Role of unusual O-glycans in intercellular signaling.
Luther et al. (2009)
22 more