› 1ejf

X-ray diffraction
2.49Å resolution

CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P23

Released:
DOI: 10.2210/pdb1ejf/pdb
PDB entry 1ejf coloured by chain, front view.
PDB entry 1ejf coloured by chain, side view.
PDB entry 1ejf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone.
Weaver AJ, Sullivan WP, Felts SJ, Owen BA, Toft DO
J Biol Chem 275 23045-52 (2000)
PMID: 10811660

Function and Biology Details

Reaction catalysed: 
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin E synthase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15185 (Residues: 1-125; Coverage: 78%)
Gene names: P23, PTGES3, TEBP
Sequence domains: CS domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P43212
Unit cell:
a: 61.802Å b: 61.802Å c: 162.888Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.268
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

Structure and mechanism of the Hsp90 molecular chaperone machinery.
Pearl et al. (2006)
14 more

16 mentions without citation

Identification and development of mPGES-1 inhibitors: where we are at?
Chang et al. (2011)
15 more