› 1em2

X-ray diffraction
2.2Å resolution

Star-related lipid transport domain of MLN64

Released:
DOI: 10.2210/pdb1em2/pdb
PDB entry 1em2 coloured by chain, front view.
PDB entry 1em2 coloured by chain, side view.
PDB entry 1em2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and lipid transport mechanism of a StAR-related domain.
Tsujishita Y, Hurley JH
Nat Struct Biol 7 408-14 (2000)
PMID: 10802740

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
StAR-related lipid transfer protein 3 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 26.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14849 (Residues: 216-444; Coverage: 52%)
Gene names: CAB1, MLN64, STARD3
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

1 bound ligand:
Ligand TAR 1 x TAR
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3121
Unit cell:
a: 83.417Å b: 83.417Å c: 81.946Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.207 0.264
Expression system: Escherichia coli

Quick links

Citations

91 review citations

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Miller et al. (2011)
90 more

19 mentions without citation

Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.
Rone et al. (2009)
18 more