› 1emr

X-ray diffraction
3.5Å resolution

CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF)

Released:
DOI: 10.2210/pdb1emr/pdb
PDB entry 1emr coloured by chain, front view.
PDB entry 1emr coloured by chain, side view.
PDB entry 1emr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Robinson RC, Heath JK, Hawkins N, Samal B, Jones EY, Betzel C

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147171 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukemia inhibitory factor Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 17.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15018 (Residues: 44-202; Coverage: 88%)
Gene names: HILDA, LIF
Sequence domains: LIF / OSM family
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: C2
Unit cell:
a: 61.5Å b: 45.3Å c: 77.7Å
α: 90° β: 112.3° γ: 90°
R-values:
R R work R free
0.191 0.191 0.293
Expression system: Escherichia coli

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