› 1esl

X-ray diffraction
2Å resolution

INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS

Released:
DOI: 10.2210/pdb1esl/pdb
PDB entry 1esl coloured by chain, front view.
PDB entry 1esl coloured by chain, side view.
PDB entry 1esl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK
Nature 367 532-8 (1994)
PMID: 7509040

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147771 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E-selectin Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16581 (Residues: 22-183; Coverage: 28%)
Gene names: ELAM1, SELE
Sequence domains:
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 34.38Å b: 73.53Å c: 77.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.164 0.239
Expression system: Not provided

Quick links

Citations

51 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
50 more

20 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
19 more