› 1euj

X-ray diffraction
1.8Å resolution

A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES

Released:
DOI: 10.2210/pdb1euj/pdb
PDB entry 1euj coloured by chain, front view.
PDB entry 1euj coloured by chain, side view.
PDB entry 1euj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases.
Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S
J Biol Chem 275 27062-8 (2000)
PMID: 10852899

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171431 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endothelial monocyte-activating polypeptide 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12904 (Residues: 147-312; Coverage: 53%)
Gene names: AIMP1, EMAP2, SCYE1
Sequence domains: Putative tRNA binding domain
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 134.01Å b: 38.34Å c: 80.99Å
α: 90° β: 112.9° γ: 90°
R-values:
R R work R free
0.213 0.208 0.232
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers.
Park et al. (2005)
9 more