› 1exa

X-ray diffraction
1.59Å resolution

ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE ACTIVE R-ENANTIOMER BMS270394.

Released:
DOI: 10.2210/pdb1exa/pdb
PDB entry 1exa coloured by chain, front view.
PDB entry 1exa coloured by chain, side view.
PDB entry 1exa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Klaholz BP, Mitschler A, Belema M, Zusi C, Moras D
Proc Natl Acad Sci U S A 97 6322-7 (2000)
PMID: 10841540

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 27.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13631 (Residues: 178-423; Coverage: 54%)
Gene names: NR1B3, RARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand 394 1 x 394
Ligand LMU 1 x LMU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P41212
Unit cell:
a: 59.672Å b: 59.672Å c: 155.545Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.25
Expression system: Escherichia coli

Quick links

Citations

9 review citations

RAR and RXR modulation in cancer and metabolic disease.
Altucci et al. (2007)
8 more

7 mentions without citation

Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Klaholz et al. (2000)
6 more