› 1exz

X-ray diffraction
2.3Å resolution

STRUCTURE OF STEM CELL FACTOR

Released:
DOI: 10.2210/pdb1exz/pdb
PDB entry 1exz coloured by chain, front view.
PDB entry 1exz coloured by chain, side view.
PDB entry 1exz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.
Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP
Proc Natl Acad Sci U S A 97 7732-7 (2000)
PMID: 10884405

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-149312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble KIT ligand Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 141 amino acids
Theoretical weight: 16.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21583 (Residues: 26-166; Coverage: 57%)
Gene names: KITLG, MGF, SCF
Sequence domains: Stem cell factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

3 bound ligands:
Ligand CA 2 x CA
Ligand SM 4 x SM
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 36.154Å b: 87.526Å c: 79.434Å
α: 90° β: 97.76° γ: 90°
R-values:
R R work R free
0.223 0.223 0.294
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations.
Heinrich et al. (2002)
29 more

7 mentions without citation

Known Mutations at the Cause of Alpha-1 Antitrypsin Deficiency an Updated Overview of SERPINA1 Variation Spectrum.
Seixas et al. (2021)
6 more