1f0j

X-ray diffraction
1.77Å resolution

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B

Released:

Function and Biology Details

Reaction catalysed:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-170460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3',5'-cyclic-AMP phosphodiesterase 4B Chains: A, B
Molecule details ›
Chains: A, B
Length: 377 amino acids
Theoretical weight: 43.32 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q07343 (Residues: 324-700; Coverage: 51%)
Gene names: DPDE4, PDE4B
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: C2221
Unit cell:
a: 104.54Å b: 159.58Å c: 109.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.223
Expression system: unidentified baculovirus