› 1f0m

X-ray diffraction
2.2Å resolution

MONOMERIC STRUCTURE OF THE HUMAN EPHB2 SAM (STERILE ALPHA MOTIF) DOMAIN

Released:
DOI: 10.2210/pdb1f0m/pdb
PDB entry 1f0m coloured by chain, front view.
PDB entry 1f0m coloured by chain, side view.
PDB entry 1f0m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Monomeric structure of the human EphB2 sterile alpha motif domain.
Thanos CD, Faham S, Goodwill KE, Cascio D, Phillips M, Bowie JU
J Biol Chem 274 37301-6 (1999)
PMID: 10601296

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
EphB2/CTF2 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P29323 (Residues: 905-985; Coverage: 8%)
Gene names: DRT, EPHB2, EPHT3, EPTH3, ERK, HEK5, TYRO5
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P43212
Unit cell:
a: 54.837Å b: 54.837Å c: 65.545Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.243 0.264

Quick links

Citations

5 review citations

The many faces of SAM.
Qiao et al. (2005)
4 more

1 mention without citation

The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle.
Kwan et al. (2007)