› 1f81

Solution NMR

SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP

Released:
DOI: 10.2210/pdb1f81/pdb
PDB entry 1f81 coloured by chain, ensemble of 20 models, front view.
PDB entry 1f81 coloured by chain, ensemble of 20 models, side view.
PDB entry 1f81 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP.
De Guzman RN, Liu HY, Martinez-Yamout M, Dyson HJ, Wright PE
J Mol Biol 303 243-53 (2000)
PMID: 11023789

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone lysine acetyltransferase CREBBP Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 10 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45481 (Residues: 1764-1849; Coverage: 4%)
Gene names: Cbp, Crebbp
Sequence domains: TAZ zinc finger
Structure domains: TAZ domain

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing molecular dynamics matrix relaxation torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Intrinsically unstructured proteins and their functions.
Dyson et al. (2005)
12 more

11 mentions without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)
10 more