1fb8

X-ray diffraction
2.4Å resolution

STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
PDBe Complex ID:
PDB-CPX-193982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UN19 (Residues: 148-273; Coverage: 45%)
Gene names: BAM32, DAPP1, HSPC066
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: I4
Unit cell:
a: 83.38Å b: 83.38Å c: 38.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.272
Expression system: Escherichia coli