› 1fbp

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM

Released:
DOI: 10.2210/pdb1fbp/pdb
PDB entry 1fbp coloured by chain, front view.
PDB entry 1fbp coloured by chain, side view.
PDB entry 1fbp coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium.
Ke HM, Zhang YP, Lipscomb WN
Proc Natl Acad Sci U S A 87 5243-7 (1990)
PMID: 2164670

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132778 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-1,6-bisphosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 36.5 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P00636 (Residues: 2-336; Coverage: 99%)
Gene names: FBP, FBP1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand F6P 2 x F6P
Ligand MG 2 x MG
Ligand AMP 2 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 61.6Å b: 166.6Å c: 80Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 not available
Expression system: Not provided

Quick links

Citations

2 review citations

Structural trees for protein superfamilies.
Efimov AV. (1997)
1 more

9 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
8 more