› 1fby

X-ray diffraction
2.25Å resolution

CRYSTAL STRUCTURE OF THE HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO 9-CIS RETINOIC ACID

Released:
DOI: 10.2210/pdb1fby/pdb
PDB entry 1fby coloured by chain, front view.
PDB entry 1fby coloured by chain, side view.
PDB entry 1fby coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.
Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D
EMBO J 19 2592-601 (2000)
PMID: 10835357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148719 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 239 amino acids
Theoretical weight: 26.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 224-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 9CR 2 x 9CR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 66.325Å b: 86.358Å c: 90.527Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.263
Expression system: Escherichia coli

Quick links

Citations

32 review citations

RAR and RXR modulation in cancer and metabolic disease.
Altucci et al. (2007)
31 more

32 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
31 more