› 1fch

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5

Released:
DOI: 10.2210/pdb1fch/pdb
PDB entry 1fch coloured by chain, front view.
PDB entry 1fch coloured by chain, side view.
PDB entry 1fch coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5.
Gatto GJ, Geisbrecht BV, Gould SJ, Berg JM
Nat Struct Biol 7 1091-5 (2000)
PMID: 11101887

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-156216 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisomal targeting signal 1 receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 368 amino acids
Theoretical weight: 40.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50542 (Residues: 272-639; Coverage: 58%)
Gene names: PEX5, PXR1
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain
PTS1-CONTAINING PEPTIDE Chains: C, D
Molecule details ›
Chains: C, D
Length: 5 amino acids
Theoretical weight: 639 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 137.96Å b: 73.51Å c: 87.56Å
α: 90° β: 120.78° γ: 90°
R-values:
R R work R free
0.194 0.194 0.224
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

51 review citations

Peroxisome biogenesis disorders.
Steinberg et al. (2006)
50 more

24 mentions without citation

BUB1 and BUBR1: multifaceted kinases of the cell cycle.
Bolanos-Garcia et al. (2011)
23 more