› 1fck

X-ray diffraction
2.2Å resolution

STRUCTURE OF DICERIC HUMAN LACTOFERRIN

Released:
DOI: 10.2210/pdb1fck/pdb
PDB entry 1fck coloured by chain, front view.
PDB entry 1fck coloured by chain, side view.
PDB entry 1fck coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin.
Baker HM, Baker CJ, Smith CA, Baker EN
J Biol Inorg Chem 5 692-8 (2000)
PMID: 11128996

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactotransferrin Chain: A
Molecule details ›
Chain: A
Length: 692 amino acids
Theoretical weight: 76.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02788 (Residues: 21-710; Coverage: 100%)
Gene names: GIG12, LF, LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand CO3 2 x CO3
Ligand CE 2 x CE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P212121
Unit cell:
a: 154.9Å b: 97.1Å c: 56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.257

Quick links

Citations

4 review citations

Lactoferrin, a Pleiotropic Protein in Health and Disease.
Mayeur et al. (2016)
3 more

7 mentions without citation

Lactoferrin a multiple bioactive protein: an overview.
García-Montoya et al. (2012)
6 more