› 1fgi

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR

Released:
DOI: 10.2210/pdb1fgi/pdb
PDB entry 1fgi coloured by chain, front view.
PDB entry 1fgi coloured by chain, side view.
PDB entry 1fgi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR, Schlessinger J
Science 276 955-60 (1997)
PMID: 9139660

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 35.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11362 (Residues: 456-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SU1 2 x SU1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: C2
Unit cell:
a: 208.49Å b: 57.79Å c: 65.53Å
α: 90° β: 107.68° γ: 90°
R-values:
R R work R free
0.19 0.19 0.27
Expression system: Spodoptera frugiperda

Quick links

Citations

77 review citations

Signaling--2000 and beyond.
Hunter T. (2000)
76 more

15 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
14 more