› 1fic

X-ray diffraction
2.5Å resolution

STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT

Released:
DOI: 10.2210/pdb1fic/pdb
PDB entry 1fic coloured by chain, front view.
PDB entry 1fic coloured by chain, side view.
PDB entry 1fic coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen.
Yee VC, Pratt KP, Côté HC, Trong IL, Chung DW, Davie EW, Stenkamp RE, Teller DC
Structure 5 125-38 (1997)
PMID: 9016719

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrinogen gamma chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 269 amino acids
Theoretical weight: 30.24 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02679 (Residues: 169-433; Coverage: 62%)
Gene names: FGG, PRO2061
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: R3
Unit cell:
a: 164.65Å b: 164.65Å c: 84.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.171 0.244
Expression system: Komagataella pastoris

Quick links

Citations

23 review citations

Fibrinogen and fibrin structure and functions.
Mosesson MW. (2005)
22 more

5 mentions without citation

Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors.
Lancellotti et al. (2008)
4 more