› 1fp5

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE ANALYSIS OF THE HUMAN IGE-FC CEPSILON3-CEPSILON4 FRAGMENT.

Released:
DOI: 10.2210/pdb1fp5/pdb
PDB entry 1fp5 coloured by chain, front view.
PDB entry 1fp5 coloured by chain, side view.
PDB entry 1fp5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human IgE-Fc C epsilon 3-C epsilon 4 reveals conformational flexibility in the antibody effector domains.
Wurzburg BA, Garman SC, Jardetzky TS
Immunity 13 375-85 (2000)
PMID: 11021535

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin heavy constant epsilon Chain: A
Molecule details ›
Chain: A
Length: 222 amino acids
Theoretical weight: 24.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01854 (Residues: 211-427; Coverage: 40%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P4212
Unit cell:
a: 105.6Å b: 105.6Å c: 47.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.27
Expression system: Trichoplusia ni

Quick links

Citations

24 review citations

IgE in allergy and asthma today.
Gould et al. (2008)
23 more

5 mentions without citation

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Quan et al. (2021)
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