› 1fqe

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURES OF MUTANT (K206A) THAT ABOLISH THE DILYSINE INTERACTION IN THE N-LOBE OF HUMAN TRANSFERRIN

Released:
DOI: 10.2210/pdb1fqe/pdb
PDB entry 1fqe coloured by chain, front view.
PDB entry 1fqe coloured by chain, side view.
PDB entry 1fqe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures and iron release properties of mutants (K206A and K296A) that abolish the dilysine interaction in the N-lobe of human transferrin.
Nurizzo D, Baker HM, He QY, MacGillivray RT, Mason AB, Woodworth RC, Baker EN
Biochemistry 40 1616-23 (2001)
PMID: 11327820

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 36.55 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: P02787 (Residues: 20-350; Coverage: 49%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand FE 1 x FE
Ligand CO3 1 x CO3
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 43.9Å b: 57.3Å c: 135.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.237
Expression system: Mesocricetus auratus

Quick links

Citations

4 review citations

Lactoferrin and transferrin: functional variations on a common structural framework.
Baker et al. (2002)
3 more