1ftn

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
GTP + H(2)O = GDP + phosphate

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-158275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transforming protein RhoA Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 21.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61586 (Residues: 1-193; Coverage: 100%)
Gene names: ARH12, ARHA, RHO12, RHOA
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P212121
Unit cell:
a: 31.92Å b: 65.96Å c: 83.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.304
Expression system: Escherichia coli