› 1fy1

X-ray diffraction
2.5Å resolution

[R23S,F25E]HBP, A MUTANT OF HUMAN HEPARIN BINDING PROTEIN (CAP37)

Released:
DOI: 10.2210/pdb1fy1/pdb
PDB entry 1fy1 coloured by chain, front view.
PDB entry 1fy1 coloured by chain, side view.
PDB entry 1fy1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding.
Kastrup JS, Linde V, Pedersen AK, Stoffer B, Iversen LF, Larsen IK, Rasmussen PB, Flodgaard HJ, Bjørn SE
Proteins 42 442-51 (2001)
PMID: 11170199

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Azurocidin Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P20160 (Residues: 27-251; Coverage: 97%)
Gene name: AZU1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand EOH 1 x EOH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P212121
Unit cell:
a: 38.72Å b: 66.56Å c: 102.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.294
Expression system: unidentified baculovirus

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Citations

1 review citation

Targeting bacterial endotoxin: two sides of a coin.
Bosshart et al. (2007)
4 other articles