› 1g13

X-ray diffraction
2Å resolution

HUMAN GM2 ACTIVATOR STRUCTURE

Released:
DOI: 10.2210/pdb1g13/pdb
PDB entry 1g13 coloured by chain, front view.
PDB entry 1g13 coloured by chain, side view.
PDB entry 1g13 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human GM2-activator protein with a novel beta-cup topology.
Wright CS, Li SC, Rastinejad F
J Mol Biol 304 411-22 (2000)
PMID: 11090283

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-148206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ganglioside GM2 activator Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17900 (Residues: 32-193; Coverage: 95%)
Gene name: GM2A
Sequence domains: ML domain
Structure domains: Ganglioside GM2 activator

Ligands and Environments

1 bound ligand:
Ligand EPE 1 x EPE
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P212121
Unit cell:
a: 63.42Å b: 85.63Å c: 120.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.258
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.
Kolter et al. (2005)
15 more

3 mentions without citation

Improving the population genetics toolbox for the study of the African malaria vector Anopheles nili: microsatellite mapping to chromosomes.
Peery et al. (2011)
2 more