› 1g1r

X-ray diffraction
3.4Å resolution

Crystal structure of P-selectin lectin/EGF domains complexed with SLeX

Released:
DOI: 10.2210/pdb1g1r/pdb
PDB entry 1g1r coloured by chain, front view.
PDB entry 1g1r coloured by chain, side view.
PDB entry 1g1r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
Somers WS, Tang J, Shaw GD, Camphausen RT
Cell 103 467-79 (2000)
PMID: 11081633

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
P-selectin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 162 amino acids
Theoretical weight: 19.13 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16109 (Residues: 42-199; Coverage: 20%)
Gene names: GMRP, GRMP, SELP
Sequence domains: Lectin C-type domain
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: MAG, GAL, SIA, FUC
Carbohydrate polymer
2 bound ligands:
Ligand CA 4 x CA
Ligand MRD 2 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 81.14Å b: 60.52Å c: 91.44Å
α: 90° β: 103.28° γ: 90°
R-values:
R R work R free
0.227 0.227 0.322
Expression system: Cricetulus griseus

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Citations

94 review citations

Neutrophils, from marrow to microbes.
Borregaard N. (2010)
93 more

9 mentions without citation

Rolling cell adhesion.
McEver et al. (2010)
8 more