› 1g1t

X-ray diffraction
1.5Å resolution

CRYSTAL STRUCTURE OF E-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH SLEX

Released:
DOI: 10.2210/pdb1g1t/pdb
PDB entry 1g1t coloured by chain, front view.
PDB entry 1g1t coloured by chain, side view.
PDB entry 1g1t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
Somers WS, Tang J, Shaw GD, Camphausen RT
Cell 103 467-79 (2000)
PMID: 11081633

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147771 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
E-selectin Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 18.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16581 (Residues: 22-178; Coverage: 27%)
Gene names: ELAM1, SELE
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: MAG, GAL, SIA, FUC
Carbohydrate polymer
1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 34.506Å b: 72.387Å c: 77.576Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.217
Expression system: Cricetulus griseus

Quick links

Citations

92 review citations

Neutrophils, from marrow to microbes.
Borregaard N. (2010)
91 more

31 mentions without citation

Lectins: getting familiar with translators of the sugar code.
André et al. (2015)
30 more