› 1g5m

Solution NMR

HUMAN BCL-2, ISOFORM 1

Released:
DOI: 10.2210/pdb1g5m/pdb
PDB entry 1g5m coloured by chain, front view.
PDB entry 1g5m coloured by chain, side view.
PDB entry 1g5m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the antiapoptotic protein bcl-2.
Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW
Proc Natl Acad Sci U S A 98 3012-7 (2001)
PMID: 11248023

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator Bcl-2 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10415 (Residues: 1-207; Coverage: 70%)
Gene name: BCL2
Sequence domains:
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

65 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
64 more

40 mentions without citation

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.
Azmi et al. (2009)
39 more