› 1g83

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF FYN SH3-SH2

Released:
DOI: 10.2210/pdb1g83/pdb
PDB entry 1g83 coloured by chain, front view.
PDB entry 1g83 coloured by chain, side view.
PDB entry 1g83 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME
J Biol Chem 276 17199-205 (2001)
PMID: 11278857

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P06241 (Residues: 82-246; Coverage: 31%)
Gene name: FYN
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 39.97Å b: 89.96Å c: 60.27Å
α: 90° β: 101.44° γ: 90°
R-values:
R R work R free
0.214 0.214 0.277
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

Structure and regulation of Src family kinases.
Boggon et al. (2004)
11 more

6 mentions without citation

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Palomero et al. (2014)
5 more