› 1g84

Solution NMR

THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE

Released:
DOI: 10.2210/pdb1g84/pdb
PDB entry 1g84 coloured by chain, ensemble of 15 models, front view.
PDB entry 1g84 coloured by chain, ensemble of 15 models, side view.
PDB entry 1g84 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
McDonnell JM, Calvert R, Beavil RL, Beavil AJ, Henry AJ, Sutton BJ, Gould HJ, Cowburn D
Nat Struct Biol 8 437-41 (2001)
PMID: 11323720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin heavy constant epsilon Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01854 (Residues: 106-210; Coverage: 19%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: structures calculated using DYANA
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

IgE in allergy and asthma today.
Gould et al. (2008)
14 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)