› 1g8q

X-ray diffraction
1.6Å resolution

CRYSTAL STRUCTURE OF HUMAN CD81 EXTRACELLULAR DOMAIN, A RECEPTOR FOR HEPATITIS C VIRUS

Released:
DOI: 10.2210/pdb1g8q/pdb
PDB entry 1g8q coloured by chain, front view.
PDB entry 1g8q coloured by chain, side view.
PDB entry 1g8q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.
Kitadokoro K, Bordo D, Galli G, Petracca R, Falugi F, Abrignani S, Grandi G, Bolognesi M
EMBO J 20 12-8 (2001)
PMID: 11226150

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD81 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 90 amino acids
Theoretical weight: 9.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60033 (Residues: 113-202; Coverage: 38%)
Gene names: CD81, TAPA1, TSPAN28
Sequence domains: Tetraspanin family
Structure domains: Tetraspanin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P21
Unit cell:
a: 31.485Å b: 77.172Å c: 38.462Å
α: 90° β: 107.39° γ: 90°
R-values:
R R work R free
0.188 0.188 0.238
Expression system: Escherichia coli

Quick links

Citations

51 review citations

Tetraspanin functions and associated microdomains.
Hemler ME. (2005)
50 more

25 mentions without citation

Hepatitis C Virus Structure: Defined by What It Is Not.
Dearborn et al. (2020)
24 more