1g9n

X-ray diffraction
2.9Å resolution

HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-224969 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Surface protein gp120 Chain: G
Molecule details ›
Chain: G
Length: 313 amino acids
Theoretical weight: 34.84 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P35961 (Residues: 82-479; Coverage: 38%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
T-cell surface glycoprotein CD4 Chain: C
Molecule details ›
Chain: C
Length: 185 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01730 (Residues: 26-210; Coverage: 43%)
Gene name: CD4
Sequence domains:
Structure domains: Immunoglobulins
ANTIBODY 17B, LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
Structure domains: Immunoglobulins
ANTIBODY 17B, HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 174.98Å b: 81.71Å c: 74.48Å
α: 90° β: 90.37° γ: 90°
R-values:
R R work R free
0.207 0.207 0.295
Expression systems:
  • Drosophila melanogaster
  • Cricetulus griseus
  • Mus musculus