› 1gkn

Solution NMR

Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)

Released:
DOI: 10.2210/pdb1gkn/pdb
PDB entry 1gkn coloured by chain, ensemble of 24 models, front view.
PDB entry 1gkn coloured by chain, ensemble of 24 models, side view.
PDB entry 1gkn coloured by chain, ensemble of 24 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.
Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN
Cell 108 769-80 (2002)
PMID: 11955431

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.21 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P17927 (Residues: 941-1065; Coverage: 6%)
Gene names: C3BR, CR1
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MOLECULAR DYNAMICS SIMULATED ANNEALING
Expression system: Komagataella pastoris

Quick links

Citations

15 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
14 more

7 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
6 more