› 1gri

X-ray diffraction
3.1Å resolution

GRB2

Released:
DOI: 10.2210/pdb1gri/pdb
PDB entry 1gri coloured by chain, front view.
PDB entry 1gri coloured by chain, side view.
PDB entry 1gri coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the mammalian Grb2 adaptor.
Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A
Science 268 291-3 (1995)
PMID: 7716522

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158872 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 217 amino acids
Theoretical weight: 25.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 1-217; Coverage: 100%)
Gene names: ASH, GRB2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P43
Unit cell:
a: 88.87Å b: 88.87Å c: 97.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 not available
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Regulation, substrates and functions of src.
Brown et al. (1996)
23 more

37 mentions without citation

In-Cell Labeling and Mass Spectrometry for Systems-Level Structural Biology.
Chavez et al. (2022)
36 more