› 1guh

X-ray diffraction
2.6Å resolution

Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the MU and PI class enzymes

Released:
DOI: 10.2210/pdb1guh/pdb
PDB entry 1guh coloured by chain, front view.
PDB entry 1guh coloured by chain, side view.
PDB entry 1guh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.
Sinning I, Kleywegt GJ, Cowan SW, Reinemer P, Dirr HW, Huber R, Gilliland GL, Armstrong RN, Ji X, Board PG
J Mol Biol 232 192-212 (1993)
PMID: 8331657

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase A1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 221 amino acids
Theoretical weight: 25.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08263 (Residues: 2-222; Coverage: 100%)
Gene name: GSTA1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSB 4 x GSB
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 100.8Å b: 95.4Å c: 105.2Å
α: 90° β: 92.4° γ: 90°
R-values:
R R work R free
0.229 0.229 not available
Expression system: Not provided

Quick links

Citations

29 review citations

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
Hayes et al. (1995)
28 more

8 mentions without citation

The molecular refractive function of lens γ-Crystallins.
Zhao et al. (2011)
7 more