1gv7

X-ray diffraction
2.1Å resolution

ARH-I, an angiogenin/RNase A chimera

Released:
Source organism: Homo sapiens
Primary publication:
Guest-host crosstalk in an angiogenin-RNase A chimeric protein.
Biochemistry 41 10482-9 (2002)
PMID: 12173935

Function and Biology Details

Reaction catalysed:
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
UniProt:
  • Canonical: P61823 (Residues: 32-150; Coverage: 93%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21212
Unit cell:
a: 38.547Å b: 64.199Å c: 61.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.274
Expression system: Escherichia coli str. K-12 substr. W3110