› 1gxe

Solution NMR

Central domain of cardiac myosin binding protein C

Released:
DOI: 10.2210/pdb1gxe/pdb
PDB entry 1gxe coloured by chain, ensemble of 10 models, front view.
PDB entry 1gxe coloured by chain, ensemble of 10 models, side view.
PDB entry 1gxe coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): implications for multidomain assembly and causes for cardiomyopathy.
Idowu SM, Gautel M, Perkins SJ, Pfuhl M
J Mol Biol 329 745-61 (2003)
PMID: 12787675

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172117 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myosin-binding protein C, cardiac-type Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14896 (Residues: 641-770; Coverage: 10%)
Gene name: MYBPC3
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Cardiac myosin binding protein C: its role in physiology and disease.
Flashman et al. (2004)
7 more

7 mentions without citation

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
Nag et al. (2017)
6 more